Towards an Achievable Performance for the Loop Nests

Numerous code optimization techniques, including loop nest optimizations, have been developed over the last four decades. Loop optimization techniques transform loop nests to improve the performance of the code on a target architecture, including exposing parallelism. Finding and evaluating an optimal, semantic-preserving sequence of transformations is a complex problem. The sequence is guided using heuristics and/or analytical models and there is no way of knowing how close it gets to optimal performance or if there is any headroom for improvement. This paper makes two contributions. First, it uses a comparative analysis of loop optimizations/transformations across multiple compilers to determine how much headroom may exist for each compiler. And second, it presents an approach to characterize the loop nests based on their hardware performance counter values and a Machine Learning approach that predicts which compiler will generate the fastest code for a loop nest. The prediction is made for both auto-vectorized, serial compilation and for auto-parallelization. The results show that the headroom for state-of-the-art compilers ranges from 1.10x to 1.42x for the serial code and from 1.30x to 1.71x for the auto-parallelized code. These results are based on the Machine Learning predictions.Comment: Accepted at the 31st International Workshop on Languages and Compilers for Parallel Computing (LCPC 2018

Grau de malignidade em ependimomas : cariometria, histopatologia e imuno-histoquimica

Orientador: Affonso AntoniukTese (doutorado) - Setor de Ciencias da Saude da Universidade Federal do ParanaResumo: Foram selecionados 40 casos de tumores de baixo e de alto grau histológico de malignidade derivados de epêndima, medindo-se neles o volume dos núcleos, através de cariometria com ocular micrométrica, em cortes histológicos submetidos a coloração por métodos histológico (HE) e imuno-histoquímico (PAP-GFAP). Em comparação com 10 casos de controles normais, correlacionou-se o aumento de volume nuclear com a variação de celularidade e a positividade da coloração imuno-histoquímica com o grau histológico de malignidade dos ependimomas. No epêndima a celularidade média é baixa (25 c/CGA) para um volume nuclear médio baixo (70 fim3), sendo as células ependimárias em sua maioria GFAP negativas (75%). No ependimoma a celularidade e volume nuclear médios são maiores (50 c/CGA e 140 fim3) com uma variação na imuno-histoquímica, sendo as células GFAP positivas na maioria (70%). No ependimoma anaplásico a celularidade e o volume nuclear médios são ainda maiores (85 c/ CGA e 200 fim3) e ocorre um retorno aproximado ao padrão imuno-histoquímico do epêndima normal, sendo (70%) de suas células GFAP negativas.Abstract: After selection, 40 cases of ependymomas and anaplastic ependymomas were submitted to cariometry with simple micrometric occular, using histologic slides stained with HE and PAP-GFAP methods. In comparision to 10 cases of normal ependyma, the increase in nuclear volumen was correlated with the variation of the cell population and the positivity of the immunohistochemical stain with the histological degree of malignancy of the ependymomas. In ependyma the cell count per high power field is low (+/- 25 c/hpf), the mean nuclear volumen is low (70 (im3), and the majority of the ependymal cells are GFAP negative (75%). In ependymomas the cellularity and mean nuclear volumen are greater (+ /- 50 c/hpf and 140 |im3) with a change in the immunohistochemical pattern being the GFAP positive cells the majority (70%). In anaplastic ependymomas the cellularity and mean nuclear volumen are even greater (85 c/hpf e 200 mm3) and occurs an approximate return to the immunohistochemical pattern of normal ependyma, being the majority of its cells GFAP negative (70%)

Cariometria aplicada a avaliaçao da anaplasia em tumores ependimários

Orientador: Affonso AntoniukDissertaçao (mestrado) -Universidade Federal do Paraná. Curso de Pós-Graduaçao em MorfologiaResumo: Foram realizadas 1.500 medições de volumes de núcleos, através de cariometria com ocular micrométrica simples, para comparação entre células ependimárias normais e neoplásicas, determinando-se, matematicamente, o aumento de volume que existe quando a célula normal se dediferencia em célula neoplásica.Abstract: Using cariometry, with simple micrometric ocular, measure was taken of 1,500 nuclei for comparison of the nuclear volumes between normal and neoplastic ependymal cells, demonstrating mathematically the difference that occurs with the dedifferentiation of normal into neoplastic cells

Dialogue about medicinal plants: meanings of students

O estudo teve como objetivo conhecer os significados atribuídos pelos escolares ao diálogo sobre plantas medicinais no cuidado à saúde. Pesquisa qualitativa realizada com 65 escolares de duas escolas do município de Pelotas/RS, no período de setembro de 2011 a agosto de 2012. O material analisado foi produzido ao final de 18 oficinas a partir de redações escritas por escolares e de grupos focais. Os encontros possibilitaram estimular nos educandos valores direcionados ao reconhecimento do saber familiar e o desenvolvimento do pensamento crítico sobre o uso seguro de plantas medicinais, despertando novas visões de mundo e proporcionando uma reflexão sobre as práticas de cuidado. O emprego do referencial de Geertz e Freire nas oficinas permitiu dialogar com a cultua dos escolares e problematizar situações de vida, constituindo-se em perspectiva para a prática educativa do enfermeiro.El artículo tiene como objetivo conocer los significados asignados por escolares sobre el diálogo cerca de las plantas medicinales en el cuidado de la salud. Metodología cualitativa con 65 escolares de dos escuelas del municipio de Pelotas/RS. La recolección de datos ocurrió de septiembre/2011 a agosto/2012. El material analizado fue producido al final de 18 oficinas a partir de textos escritos y grupos focales. Se observó que los encuentros permitieron estimular en los estudiantes valores dirigidos al reconocimiento del saber familiar y el desarrollo del pensamiento crítico sobre el uso seguro de las plantas medicinales, levantando nuevas visiones del mundo y proporcionando una reflexión sobre las prácticas de cuidado. El empleo del marco teórico de Geertz y Freire en las oficinas permitió el diálogo con la cultura de los escolares y discutir situaciones de vida, transcurriendo en una perspectiva para la educación de las enfermeras.This study aims to know the meanings attributed by students to dialogue about medicinal plants in health care. It is a qualitative research with 65 students of two schools in the city of Pelotas/RS, from September 2011 to August 2012. The analyzed data was produced after 18 workshops from essays written by students and focus groups. The meetings allowed us to stimulate in the students values directed to the recognition of the family knowledge and the development of critical thinking about the safe use of medicinal plants, awakening them new visions of the world and providing a reflexion on the care practices. The use of Geertz and Freire referential in the workshops allowed dialogue with the culture of the students and discuss situations of life, becoming in perspective for educational practice nurses

2007-2008 Master Class - Thomas Hecht (Piano)

Thomas Hecht Performance (November 10, 2007) - Programhttps://spiral.lynn.edu/conservatory_masterclasses/1119/thumbnail.jp

Physical Exercise Decreases Fasting Hyperglycemia in Diabetic Mice Through AMPK Activation

Introduction: The deficiency in glucose uptake in peripheral tissues and increased hepatic gluconeogenesis are physiopathological phenomena observed in type 2 diabetes patients. Physical exercise plays an important role in the improvement of glycemic profile in diabetic patients; however, the mechanisms involved in these processes have not been fully elucidated. Objective: to assess the role of AMPK protein in the glycemic control of diabetic mice after exercise. Methods: During fasting condition, the insulin tolerance test (ITT) and Western blot technique, were combined to assess the glucose homeostasis in diabetic mice (ob/ob and db/db) after a single swimming session. Results: Fasting hyperglycemia, severe insulin resistance and deficiency in the AMPk/ACC signaling in muscle and liver observed in the diabetic mice were reversed after the exercise session. The restoration of AMPK/ACC signaling reduced the expression of the gluconeogenic enzyme, PEPCk in the liver, and increased the translocation of GLUT4 in the skeletal muscle. These data indicate that the activation of AMPK/ACC pathway induced by physical exercise is important to reduce fasting glucose levels in experimental models of type 2 diabetes. These data open new insights for determination of physical activity control on the glucose homeostasis in diabetic patients.15317918